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Keep track of Carefully (one)pentobarbital will reduce the level or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the extent or impact of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital decreases amounts of amphotericin B